TB-500
TB-500 is a synthetic version of an active region of thymosin beta-4 studied in laboratory research for tissue repair and recovery. It is a research compound and is not approved by the FDA for human use.
What is TB-500?
TB-500 is a synthetic version of an active region of thymosin beta-4. TB-500 exerts its mechanism of action primarily by promoting angiogenesis and tissue repair, as demonstrated in preclinical models. It influences cellular processes involved in tissue regeneration, although direct evidence from human clinical trials remains limited.
It is best referenced by its chemistry (PubChem CID 62707662, molecular formula C38H68N10O14). TB-500 is sold and discussed for laboratory and research use only.
Key Benefits & Mechanisms
Mechanism of action
TB-500 exerts its mechanism of action primarily by promoting angiogenesis and tissue repair, as demonstrated in preclinical models. It influences cellular processes involved in tissue regeneration, although direct evidence from human clinical trials remains limited.
Research Summary
TB-500 has been examined in peer-reviewed research; representative studies are listed below. The publicly available evidence is primarily preclinical, and TB-500 is not approved by the FDA for human use.
- Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions. (2026) PubMed · PMID 41490200
- Injectable Peptide Therapy: A Primer for Orthopaedic and Sports Medicine Physicians. (2026) PubMed · PMID 41476424
- Simultaneous quantification of TB-500 and its metabolites in in-vitro experiments and rats by UHPLC-Q-Exactive orbitrap MS/MS and their screening by wound healing activities in-vitro. (2024) PubMed · PMID 38382158
Frequently asked questions about TB-500
Is TB-500 FDA approved?
No. TB-500 is not approved by the FDA for human use. It is sold for laboratory and research purposes only, and its public evidence base is primarily preclinical.
What is TB-500 studied for?
In research, TB-500 is studied for tissue repair and recovery. TB-500 exerts its mechanism of action primarily by promoting angiogenesis and tissue repair, as demonstrated in preclinical models. It influences cellular processes involved in tissue regeneration, although direct evidence from human clinical trials remains limited.
How is TB-500 stored?
Like most peptides, lyophilized TB-500 is best kept cold, dark, and dry; reconstituted material is refrigerated and used within a limited window. See the storage and reconstitution guide for details.
Legal & research status: Research use only — not approved by the FDA for human use. Sold and discussed for laboratory and research use only, not for human consumption.